11 Howard St., New York, N.Y.
Drive time: 2 hours.
The scoop: From the Alexander Calder mobile in the lobby to the paintings, sculptures and custom-made Scandinavian furniture in the public spaces and guestrooms, this is an art-centric hotel, perfect for New York’s artsy SoHo district. Opened in April, it offers airy accommodations with 11-foot-high ceilings and oversized windows.
Don’t miss: Take a self-guided art tour of SoHo, home to more than 20 galleries. Be sure to reserve time to visit the New Museum of Contemporary Art.